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So, where's the connection? A significant proportion of triple-negative breast cancers—about 70-80%—are also classified as basal-like when assessed using gene expression profiling. This overlap is why the terms are often used interchangeably, especially in clinical settings where gene expression profiling might not be readily available. Think of it this way: being triple-negative is like belonging to a club, and being basal-like is like being a subset within that club with shared characteristics. However, it's crucial to understand that not *all* triple-negative breast cancers are basal-like, and not *all* basal-like breast cancers are triple-negative. Some TNBC tumors may have different gene expression profiles that don't fit the basal-like subtype, while some basal-like tumors might express one of the hormone receptors (ER or PR) or HER2, excluding them from the triple-negative category. This distinction highlights the importance of precise characterization whenever possible to guide treatment decisions.
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