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* **iCloud backup failed**: If iCloud backup failed, make sure that your device is connected to Wi-Fi and a power source. You can also try restarting your device.
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While insulin works to lower blood glucose, **glucagon** steps in when glucose levels dip too low. Glucagon secretion is primarily regulated by blood glucose concentration. When glucose levels fall, pancreatic alpha cells respond by releasing glucagon. The precise mechanisms by which glucose regulates glucagon secretion are still being investigated, but several factors are thought to be involved. One proposed mechanism involves the ATP/ADP ratio within the alpha cell, similar to that in beta cells. However, in alpha cells, a decrease in the ATP/ADP ratio is thought to stimulate glucagon secretion. Another proposed mechanism involves the activity of ion channels, such as KATP channels and sodium channels. Hyperpolarization of the alpha cell membrane is thought to promote glucagon release.
